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ORIGINAL ARTICLES  
CMH 2012 December;18:360-367.
Published online 2012 December 24. doi:http://dx.doi.org/10.3350/cmh.2012.18.4.360
Copyright © 2012 The Korean Association for the Study of the Liver
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Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C
Seok Hoo Jeong1, Young Kul Jung1, Jae Won Yang2, Sang Jin Park2, Jong Woo Kim2, Oh Sang Kwon1, Yun Soo Kim1, Duck Joo Choi1, and Ju Hyun Kim1
1Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University of Medicine and Science, Incheon;
2Laboratory of Infectious Disease, B&C Biopharm Co. Ltd., Suwon, Korea
Corresponding Author: Young Kul Jung ,Tel: +82-32-460-8201, Fax: +82-32-460-3408, Email: 93cool@hanmail.net
ABSTRACT
Background/Aims: Sustained virologic response (SVR) for the treatment of chronic hepatitis C (CHC) may differ with ethnicity due to differences in genetic traits. This study evaluated the efficacy of peginterferon and ribavirin, and the association between IL28B genotypes and the treatment efficacy in Korean CHC patients.
Methods: This was a retrospective cohort study using data from medical records. Eighty-five CHC patients were eligible for assessment of the efficacy of antiviral therapy, and 47 patients were available for an IL28B genetic study, which was performed using the Multiplex tetra-primer PCR method for rs12979860.
Results: Overall, the early virologic response rate was 87.1%: 84.9% in HCV genotype 1 and 90.6% in genotype 2. The overall end-of-treatment virologic response rate was 81.2%: 75.5% in genotype 1 and 90.6% in genotype 2. The overall SVR rate was 81.2%: 75.5% in genotype 1 and 90.6% in genotype 2. For rs12979860, the frequencies of polymorphisms were 89% for the CC type, 11% for the CT type, and 0% for the TT type. Their overall SVR rate was 87% (39/47): 90.5% (38/42) for the CC type and 20% (1/5) for the CT type. For genotype 1, SVR rates were 88% (21/24) for the CC type and 0% (0/4) for the CT type. Multivariate analysis revealed that the IL28B-CC type was a good predictor for SVR.
Conclusions: The SVR of the combination therapy in Koreans was higher than that observed in Western countries. This finding might be attributable to the high prevalence of IL28B-CC type among Koreans, which may be a good predictor of SVR.
Keywords: Chronic hepatitis C; Peginterferon; Ribavirin; IL28B; Korea
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