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| CASE REPORTS |
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| A case of isolated metastatic hepatocellular carcinoma
arising from the pelvic bone |
| Kyu Sik Jung1, Kyeong Hye Park1, Young Eun Chon1, Sa Ra Lee2, Young Nyun Park2,
Do Yun Lee3, Jin Sil Seong4, and Jun Yong Park1 |
Departments of 1Internal Medicine, 2Pathology, 3Radiology, and 4Radiation Oncology,
Yonsei University College of Medicine, Seoul, Korea |
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Corresponding Author:
Jun Yong Park ,Tel: +82-2-2228-1949, Fax: +82-2-393-6884, Email: DRPJY@yuhs.ac |
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| ABSTRACT |
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| Reports of metastatic hepatocellular carcinoma (HCC) without a primary liver tumor are rare. Here we present a case of
isolated HCC that had metastasized to the pelvic bone without a primary focus. A 73-year-old man presented with severe
back and right-leg pain. Radiological examinations, including computed tomography (CT) and magnetic resonance
imaging (MRI), revealed a huge mass on the pelvic bone (13¡¿10 cm). He underwent an incisional biopsy, and the results
of the subsequent histological examination were consistent with metastatic hepatocellular carcinoma. The tumor cells
were positive for cytokeratin (AE1/AE3), hepatocyte paraffin 1, and glypican-3, and negative for CD56, chromogranin A,
and synaptophysin on immunohistochemical staining. Examination of the liver by CT, MRI, positron-emission tomography
scan, and angiography produced no evidence of a primary tumor. Radiotherapy and transarterial chemoembolization
were performed on the pelvic bone, followed by systemic chemotherapy. These combination treatments resulted in tumor
regression with necrotic changes. However, multiple lung metastases developed 1 year after the treatment, and the
patient was treated with additional systemic chemotherapy. |
| Keywords: Reports of metastatic hepatocellular carcinoma (HCC) without a primary liver tumor are rare. Here we present a case of
isolated HCC that had metastasized to the pelvic bone without a primary focus. A 73-year-old man presented with severe
back and right- |
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