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| ORIGINAL ARTICLES |
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| Co-expression patterns of Notch1, Snail, and p53 in grade
III hepatocellular carcinoma with postoperative
recurrence: a preliminary study |
| Sun Kyung Jang1, Gi Hong Choi2, Junjeong Choi3, Xiaoyuan Quan4, Jeong Won Jang5,
Bo Hyun Kim1, Guhung Jung4*, and Young Min Park1* |
1Hepatology Center and Laboratory of Hepatocarcinogenesis, Bundang Jesaeng General Hospital, Seongnam;
2Department of Surgery, Yonsei University College of Medicine, Seoul; 3Department of Pathology,
Yonsei University Wonju College of Medicine, Wonju; 4Department of Biological Sciences,
Seoul National University College of Medicine; 5Department of Internal Medicine,
The Catholic University of Korea College of Medicine, Seoul, Korea |
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Corresponding Author:
Young Min Park ,Tel: +82-31-779-0676, Fax: +82-31-779-0164, Email: ymp1@hotmail.com |
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| ABSTRACT |
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| Background/Aims: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53
proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). Methods: The immunoblot data for
molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for
p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC
differentiation grade III (n=47), due to its high p53 mutation rate. Results: Nineteen of the 47 patients (40.4%)
-comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship
between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5%) of the eight relapsed cases
with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller
than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter,
without any deviation in the NSP pattern. Conclusions: The results of this preliminary study suggest that the
co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of
postoperative recurrence of grade III HCC. |
| Keywords: Notch1 intracellular domain; p53; Snail; p53 mutation; Hepatocellular carcinoma |
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